formulation and evaluation of medicated chewing gum of nicotine tartrate

Formulation and Evaluation of Medicated Chewing Gums of Chlorpheniramine Maleate

The aim of the present work is development and evaluation of Chlorpheniramine maleate medicated chewing gums and to study the influence of different plasticizers on physicochemical parameters and in vitro drug release profile. Chlorpheniramine maleate is used to relieve symptoms of allergy, hay fever and common cold. Prepared formulations are evaluated for thickness, hardness, weight variation,...

Formulation of Medicated Chewing Gum of Ondansetron Hydrochloride and Its Pharmacokinetic Evaluations

An attempt has been made to formulate new chewing gum device for ondansetron hydrochloride in the form of tablet. The new drug delivery system was obtained, at room temperature, by direct compression using conventional pharmaceutical equipment. The resulting chewing gum tablets comprise a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appeara...

Randomised controlled trial of nicotine chewing-gum.

The effectiveness of 2 mg nicotine chewing-gum as an aid to stopping smoking was compared with a placebo containing 1 mg nicotine, but unbuffered, in a double-blind randomised trial. Of 58 subjects given the active gum, 27 (47%) were not smoking at one-year follow-up compared with 12 (21%) of the 58 subjects treated with placebo (p less than 0.025). By the most stringent criterion of outcome, 1...

An overview on Medicated Chewing Gum and its Applications

Formulation of corn zein chewing gum

Ipomoea turpethum R. Br. [= Operculina terpethum (Linn.) Silva Manso (Hindi—Nisoth, Pitohri), a perennial plant with a muchtwisted stem is found through out India. It is reported to be highly medicinal and is cultivated occasionally in gardens as an ornamental plant. Some hydroxy fatty acids, butulin, lupeol and sitosterol have been found in the plant. Seed gums are important vegetable products...

Plasma nicotine levels after cigarette smoking and chewing nicotine gum.

Plasma nicotine levels were measured over seven hours of smoking cigarettes (1-2 mg nicotine) in a single subject under standardised conditions, and were compared with the levels obtained from chewing-gum containing either 2 mg or 4 mg nicotine. Levels comparable to those resulting from smoking were not obtained with the 2-mg gum, but peak levels on the 4-mg gum averaged 40-1 ng/ml from the thi...